Sunday, June 5, 2011

The impact of diet and lifestyle on prostate cancer - a case for epigenetics

Well to my fellow "warrior" moms and dads (those who are treating Autism and other medical conditions in their children through many biomedical treatment approaches) this will not be surprising. We see it everyday. We see a "genetic" disorder that is being improved through dietary changes, supplementation, detox, chelation, treating yeast and bacterial overgrowth in the gut, etc. But this is pretty exciting. Anyone who has gone to a conference talking about the biomedical approach to Autism has heard about epigentics and the issue with our increasingly toxic environment making heritable changes in our genes and of course the negative health consequences that brings. So, this is pretty exciting to have more of this research come out in the mainstream. Although it really shouldn't be THAT hard to digest that our way of life has more to do with our health than just our genes. Eating healthy, organic, nutrition filled foods, exercise and stress management is good, while eating heavily processed, nutritionally void foods, not exercising and not managing stress can have a negative impact. In a word "DUH". When we flood our body with nutrients and remove toxins, it does what it does best, flourish, thrive, grow and heal. That means increases in proper immune function and cellular turnover and the ability to fight disease and cancer is increased. When we bog it down with bad food and toxins, it has to work hard to process that, it brings down immune function, or even worse stimulates it because of the food that is eaten causing auto-immunity, and therefore things like cancer can gain a foothold. So here is the article from Reuters. Maybe we're not so crazy afterall ;)


By Will Dunham

WASHINGTON Wed Jun 18, 2008 3:47pm EDT

WASHINGTON (Reuters) - Comprehensive lifestyle changes including a better diet and more exercise can lead not only to a better physique, but also to swift and dramatic changes at the genetic level, U.S. researchers said on Monday.

In a small study, the researchers tracked 30 men with low-risk prostate cancer who decided against conventional medical treatment such as surgery and radiation or hormone therapy.

The men underwent three months of major lifestyle changes, including eating a diet rich in fruits, vegetables, whole grains, legumes and soy products, moderate exercise such as walking for half an hour a day, and an hour of daily stress management methods such as meditation.

As expected, they lost weight, lowered their blood pressure and saw other health improvements. But the researchers found more profound changes when they compared prostate biopsies taken before and after the lifestyle changes.

After the three months, the men had changes in activity in about 500 genes -- including 48 that were turned on and 453 genes that were turned off.

The activity of disease-preventing genes increased while a number of disease-promoting genes, including those involved in prostate cancer and breast cancer, shut down, according to the study published in the journal Proceedings of the National Academy of Sciences.

The research was led by Dr. Dean Ornish, head of the Preventive Medicine Research Institute in Sausalito, California, and a well-known author advocating lifestyle changes to improve health.

"It's an exciting finding because so often people say, 'Oh, it's all in my genes, what can I do?' Well, it turns out you may be able to do a lot," Ornish, who is also affiliated with the University of California, San Francisco, said in a telephone interview.

"'In just three months, I can change hundreds of my genes simply by changing what I eat and how I live?' That's pretty exciting," Ornish said. "The implications of our study are not limited to men with prostate cancer."

Ornish said the men avoided conventional medical treatment for prostate cancer for reasons separate from the study. But in making that decision, they allowed the researchers to look at biopsies in people with cancer before and after lifestyle changes.

"It gave us the opportunity to have an ethical reason for doing repeat biopsies in just a three-month period because they needed that anyway to look at their clinical changes (in their prostate cancer)," Ornish said.

(Editing by Julie Steenhuysen and Xavier Briand)

No comments: